These Regulations amend the National Institute for Health and Care Excellence (Constitution and Functions) and NHS England (Functions) Regulations 2013 (S.I. 2013/259) (“2013 Regulations”). The purpose of these amendments is to introduce a power for the Secretary of State to direct the National Institute of Health and Care Excellence (“NICE”) with regard to the cost-effectiveness threshold NICE is to apply to health technologies when carrying out technology appraisals under regulation 7 of the 2013 Regulations or appraising highly specialised health technologies under regulation 8 of the 2013 Regulations.